NCT01235468

Allogenic Transplantation of Ex-vivo Expanded Cord Blood (CB)

Allogenic Transplantation of Ex-vivo Expanded CB Progenitors for Haematological Disorders

• Status: Withdrawn
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Dr. Avichai Shimoni MD · Other Government
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the safety profile and tolerability of infusion of cord blood cells expanded in the lab and to evaluated whether through the infusion of expanded cells it is possible to expedite engraftment time after transplantation.

Detailed description

Stem cell transplantation is a curative approach for patients with hematological malignancies. Umbilical cord blood is a source of stem cells for transplantation in patients with no related donor. However, in adults, the number of stem cells in a single unit, may be too low to allow engraftment, and the time to engraftment may be prolonged, increasing the risks of the transplant. In this study, we expand part of the cord blood unit, in the lab, trying to increase unit size, such that it would be suitable for adults, and would allow safe engraftment.

Conditions

• Umbilical Cord Blood
• Stem Cell Transplantation
• Hematological Malignancies

Interventions

Type	Name	Description
BIOLOGICAL	ex vivo expansion	ex-vivo expansion of cord blood for transplantation

Timeline

• Start date: 2012-06-01
• Primary completion: 2015-11-01
• Completion: 2015-11-01
• First posted: 2010-11-05
• Last updated: 2015-12-03