NCT01235325

The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients

The Effect of Vitamin K Supplementation on Bone Health Indices in Adult Crohn's Disease

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: University College Cork · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

To assess the impact of a 12 month vitamin K supplementation intervention on bone health in adult Crohn's disease patients

Detailed description

To assess the impact of 12 months of vitamin K1 supplementation (plus vitamin D and calcium supplementation to avoid deficiency of these problematic nutrients) at a level which leads to dramatically (i.e greater than 70%) reduced levels of undercarboxylated osteocalcin - a functional marker of vitamin K status, on vitamin K status, the rate of bone formation and bone resorption, using biochemical markers of bone turnover, and bone mineral density in adult patients with longstanding Crohn's disease.

Conditions

• Supplementation
• Bone Health
• Crohn's Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	phylloquinone (vitamin K1)	1000 mcg phylloquinone (vitamin K1) once daily for 12 months
DIETARY_SUPPLEMENT	placebo	placebo oil capsule

Timeline

• Start date: 2008-07-01
• Primary completion: 2010-11-01
• Completion: 2010-11-01
• First posted: 2010-11-05
• Last updated: 2010-11-09

Locations

1 site across 1 country: Ireland