NCT01233297

Antibiotic Treatment of Recurrent Episodes of Asthma in Children

Antibiotic Treatment of Recurrent Episode of Asthma in Children - a Randomised, Case-controlled Study Within the COPSAC2010 Cohort (Asthma Begins in Childhood)

• Status: Active Not Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Copenhagen Studies on Asthma in Childhood · Academic / Other
• Sex: All
• Age: 1 Year – 3 Years
• Healthy volunteers: Not accepted

Summary

Copsac has discovered that asthmatic exacerbations are as closely linked to bacterial as to viral infection. The current study will examine whether treatment of asthmatic exacerbations with macrolide antibiotics - in the abscence of clear clinical bacterial infection which would in any case precipitate antibiotic treatment - has an effect on either the particular episode, or subsequently. Macrolide antibiotics are chosen for ease of administration ensuring high compliance, antibiotic appropriacy, and anti-inflammatory properties.

Conditions

• Childhood Asthma With Acute Exacerbation

Interventions

Type	Name	Description
DRUG	Azithromycin	10 mg/kg peroral for 3 consecutive days
OTHER	Placebo mixture	Placebo mixture containing no active substance.

Timeline

• Start date: 2010-11-01
• Primary completion: 2027-10-01
• Completion: 2033-10-01
• First posted: 2010-11-03
• Last updated: 2026-03-18

Locations

2 sites across 1 country: Denmark