Trials / Completed
CompletedNCT01232842
Biomarker Study in Tissue Samples From Patients With Acute Myeloid Leukemia
Assessment of Stem Cell Heterogeneity in AML in Co-Culture Systems Using X Chromosome Inactivation Patterns
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 20 (estimated)
- Sponsor
- Children's Oncology Group · Network
- Sex
- Female
- Age
- 120 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in tissue samples from patients with acute myeloid leukemia.
Detailed description
OBJECTIVES: * Determine the frequency of acute myeloid leukemia (AML) that originates in CD33+ precursors or in which uncontrolled growth is restricted to CD33+ precursors. OUTLINE: Cryopreserved acute myeloid leukemia cell samples are separated from endothelial cell by fluorescent-activated cell sorting (FACS) and analyzed for X-chromosome inactivation patterns by cytogenetic/molecular analysis and/or Humara assay.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | cytogenetic analysis | |
| OTHER | HUMARA assay | |
| OTHER | fluorescence activated cell sorting | |
| OTHER | laboratory biomarker analysis |
Timeline
- Start date
- 2010-10-01
- Primary completion
- 2016-07-01
- First posted
- 2010-11-02
- Last updated
- 2016-07-11
Source: ClinicalTrials.gov record NCT01232842. Inclusion in this directory is not an endorsement.