NCT01232244

Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 15 (actual)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism. Oxyntomodulin, GLP-1 and glucagon are all known to regulate parameters such as appetite, food intake and induce weight loss. Therefore we want to investigate mechanistic relations between the three hormones.

Conditions

• Incretin Action
• Obesity

Interventions

Type	Name	Description
OTHER	GLP-1 infusion	1 pmol/kg/min
OTHER	Glucagon infusion	3ng/kg/min
OTHER	Oxyntomodulin infusion	3 pmol/kg/min
OTHER	GLP-1 and glucagon infusion	1 pmol/kg/min 3 ng/kg/min
OTHER	Placebo	NaCl 9 g/L infusion

Timeline

• Start date: 2010-10-01
• Primary completion: 2012-01-01
• Completion: 2012-01-01
• First posted: 2010-11-02
• Last updated: 2013-12-10

Locations

1 site across 1 country: Denmark