NCT01230632

Metabolic Phenotyping of Individuals Born Following Assisted Reproduction Techniques

Metabolic Phenotyping of Individuals Born Following Assisted Reproduction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: University of Adelaide · Academic / Other
• Sex: All
• Age: 16 Years – 26 Years
• Healthy volunteers: Accepted

Summary

This study is to compare the effects of high fat overfeeding on metabolic risk factors in children born though assisted reproduction technologies (ART) versus children conceived naturally (controls). The investigators will utilize state of the ART measures to characterize the physiological, endocrine and molecular responses to high fat overfeeding. The investigators hypothesize that children conceived following ART will have greater responses to high fat dietary challenge and that this will be associated with DNA hypermethylation of genes that are involved in lipid metabolism.

Detailed description

This study represents a novel initiative by the investigators to determine whether children conceived through ART have different metabolic responses at baseline or in response to high fat overfeeding as compared to age and body mass index-matched spontaneously conceived controls. Furthermore, the investigators will identify any differences in DNA methylation of candidate genes involved in lipid metabolism in adipose tissue and blood, to determine whether this is related to adverse outcomes during high fat overfeeding. The results from this study will help answer growing questions of the future health of In vitro fertilisation (IVF) babies, and may stimulate further research into optimising protocols for ovarian stimulation or in-vitro conditions during early blastocyst development.

Conditions

• Metabolic Syndrome
• Diabetes

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	high fat overfeeding	Dietary Supplement:3 days overfeeding

Timeline

• Start date: 2010-09-01
• Primary completion: 2013-04-01
• Completion: 2013-09-01
• First posted: 2010-10-29
• Last updated: 2013-12-10

Locations

1 site across 1 country: Australia