Trials / Completed
CompletedNCT01229956
Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia
Promoter Methylation in MLL-Rearranged Childhood AML
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 32 (estimated)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- 1 Year – 18 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of tissue from patients with cancer the in laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in tissue samples from young patients with acute myeloid leukemia.
Detailed description
OBJECTIVES: * To determine whether the pattern of global and TSG-specific promoter CpG island hypermethylation and gene silencing that we have shown characterizes MLL-rearranged (MLL-r) infant bilineage ALL is also characteristic of other subsets of MLL-r leukemia. OUTLINE: Previously collected cryopreserved cells from diagnosis are analyzed for promoter methylation via HELP arrays, gene expression arrays, and RT-qPCR. PROJECTED ACCRUAL: A total of 32 samples (8 from each of 4 biologically defined cohorts) will be analyzed.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | DNA methylation analysis | |
| GENETIC | gene expression analysis | |
| GENETIC | microarray analysis | |
| GENETIC | reverse transcriptase-polymerase chain reaction | |
| OTHER | laboratory biomarker analysis |
Timeline
- Start date
- 2010-11-01
- Primary completion
- 2016-05-01
- First posted
- 2010-10-28
- Last updated
- 2016-05-19
Source: ClinicalTrials.gov record NCT01229956. Inclusion in this directory is not an endorsement.