Trials / Completed
CompletedNCT01229124
RNA Biomarkers in Tissue Samples From Infants With Acute Myeloid Leukemia
SCOR in Targeted Therapies for Infant Leukemias Project 4: MicroRNA Sequencing of Infant AML
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 20 (estimated)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- 1 Year
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in RNA and identify biomarkers related to cancer. PURPOSE: This research study is studying RNA biomarkers in tissue samples from infants with acute myeloid leukemia.
Detailed description
OBJECTIVES: * Sequence the microRNAs present in 20 infant AML samples as a pilot study. * Compare microRNAs present in infant AML samples to infant ALL samples that are being concurrently sequenced in a separate study to identify lineage- and translocation-specific microRNAs. OUTLINE: This is a multicenter study. Previously collected cryopreserved cells from diagnosis are sequenced using reverse transcriptase-PCR.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | RNA analysis | |
| GENETIC | nucleic acid sequencing | |
| GENETIC | reverse transcriptase-polymerase chain reaction | |
| OTHER | laboratory biomarker analysis |
Timeline
- Start date
- 2010-10-01
- Primary completion
- 2016-05-01
- Completion
- 2016-05-01
- First posted
- 2010-10-27
- Last updated
- 2016-05-17
Source: ClinicalTrials.gov record NCT01229124. Inclusion in this directory is not an endorsement.