NCT01224561

Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 26 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: Female
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain, either in constitutional thinness (MC) by blocking it. The MC is a little known entity. These patients wish to grow for her and others. Can they? We have demonstrated abnormalities of hormones regulating appetite (ghrelin, PYY, GLP1 and leptin) that may participate in thinness. Furthermore, this thinness is associated with osteoporosis in 25% of true MC who is 25 years old.

Detailed description

This project aims to overfed MCs and follow the control parameters of energy metabolism. We will look for abnormalities in the adaptation to overnutrition in subjects with genetic background of thinness, which could explain the resistance to weight gain. The answer could possibly help to understand obesity.

Conditions

• Lipid Overnutrition
• Constitutional Thinness

Interventions

Type	Name	Description
BEHAVIORAL	Lipid overnutrition	During 4 months, the daily caloric intake will be increased by about 70 g fat as butter 20 grams, 100 grams of cheese (Emmental) and 40 grams of almonds. This overnutrition corresponds to an excess of 760 kcal / day or 21,280 calories for the period and then taken to a theoretical 2.4 kg of fat (1 kg fat = 9000 kcal).

Timeline

• Start date: 2008-03-01
• Primary completion: 2011-01-01
• Completion: 2011-01-01
• First posted: 2010-10-20
• Last updated: 2011-05-05

Locations

3 sites across 1 country: France