NCT01219595

Cranberry Proanthocyanidins for Modification of Intestinal E. Coli Flora and Prevention of Urinary Tract Infections in UTI-Susceptible Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 65 (actual)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of the research is to determine if eating sweetened, dried cranberries or strawberry fruit pieces will increase the types of different E. coli bacteria in the intestines which may reduce the likelihood of a major, or highly harmful urinary type of bacteria which cause urinary tract infections in susceptible women.

Detailed description

This is a research study about the number and types of bacteria that cause urinary tract infections (E. coli strains) that are present in the intestine. The bacteria will be collected and analyzed before and after eating either sweetened, dried cranberries or strawberry fruit pieces. This study will help us learn more about whether or not the components of consumed sweetened, dried cranberries or strawberry fruit pieces reduce the numbers of harmful E. coli bacteria in the vaginal and intestinal tracts, thereby reducing the number of urinary tract infections among women.

Conditions

• Urinary Tract Infection

Interventions

Type	Name	Description
OTHER	Sweetened, dried cranberries	Women in Arm 1 will consume one serving (1/3 cup; 42 g) of sweetened, dried cranberries each day for two weeks.
OTHER	Strawberry Fruit Pieces	1 serving (1/3 cup; 42 g) of strawberry fruit pieces each day for three separate, two-week periods. Each two week period will be separated by a two-week interval.
OTHER	Sweetened, dried cranberries	1 serving (1/3 cup; 42 g) of sweetened, dried cranberries each day for three separate, two-week periods. Each two week period will be separated by a two-week interval.
OTHER	Sweetened, dried cranberries	1 serving (1/3 cup; 42 g) of sweetened, dried cranberries each day for one 4-week period.
OTHER	Strawberry Fruit Pieces	1 serving (1/3 cup; 42 g) of strawberry fruit pieces each day for one 4-week period.
OTHER	Observation	Subjects in the non-UTI susceptible group will have one visit where one vaginal and one rectal swab will be collected.

Timeline

• Start date: 2010-09-01
• Primary completion: 2012-09-01
• Completion: 2012-09-01
• First posted: 2010-10-13
• Last updated: 2016-01-29

Locations

1 site across 1 country: United States