NCT01219504

Evaluation of the Impact of Embryo Biopsy on the Reproductive Potential of Embryos Undergoing In Vitro Fertilization (IVF)

Evaluation of the Impact of Embryo Biopsy on the Reproductive Potential of Embryos Undergoing IVF

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 200 (actual)
• Sponsor: Reproductive Medicine Associates of New Jersey · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

To assess the impact of embryo biopsy on the reproductive potential of human embryos.

Detailed description

This study will recruit patients from the NY/NJ/CT/eastern PA area only. All patients will undergo an in vitro fertilization (IVF) cycle with hormonal stimulation and an egg retrieval procedure as deemed appropriate for their diagnosis. Following biopsy, the embryos will be transferred. There will be no delay in the time of transfer as no cells will be analyzed prior to transfer. On day 3 or day 5 of embryo development, all patients will undergo a two (2) embryo transfer. The embryos selected for transfer will be the 2 morphologically best of the embryo cohort. Once selected for transfer, the embryos will be randomized so that one will be biopsied and the other will be transferred without undergoing biopsy. The embryo randomized to biopsy will have a single cell biopsied. Following delivery, buccal swabs will be collected from infants.

Conditions

• Each Patient is Both Case and Control
• 1 Embryo Will be Biopsied and 1 Embryo is Not

Timeline

• Start date: 2008-04-01
• Primary completion: 2012-09-01
• Completion: 2012-09-01
• First posted: 2010-10-13
• Last updated: 2013-01-23

Locations

3 sites across 1 country: United States