Trials / Completed

CompletedNCT01219439

Evaluation of Discarded Laboratory Pathological Specimens and Media

Laboratory Evaluation of IVF Discarded Pathological Specimens and Media for Optimization of Techniques for Assisted Reproduction

Status: Completed
Phase: —
Study type: Observational
Enrollment: 10,000 (actual)

Sponsor: Reproductive Medicine Associates of New Jersey · Academic / Other
Sex: All
Age: 18 Years – 65 Years
Healthy volunteers: Accepted

Summary

The researchers propose to investigate the causes, incidence, and time-related events of chromosomal and physiologic abnormalities as they relate to patient diagnosis, fertility drugs utilized, and in vitro laboratory culture conditions.

Detailed description

We propose to identify a group of parameters that have significant predictive value for assisted reproductive technology outcomes. We seek to test, standardize and implement better methods for the freezing of oocytes and sperm prior to these techniques being used in the clinical setting. We seek to develop new methods to optimize the determination of genes and chromosomes in gametes. We hope to develop new cell surgery or micromanipulation techniques (e.g. use of cell drills and lasers in order to enhance the efficiency of procedures such as ICSI, assisted hatching, biopsy) as well as other manipulations. We will test the safety and efficiency of micro fluidics and automation in the Embryology lab. This has the potential to reduce cost, human errors, temperature and physical changes. We hope to develop new methods and media and media supplements normally found in the reproductive tract that allow for higher survival of gametes in vitro. We will also test the proficiency of laboratory staff members on techniques and/or procedures performed in the in-vitro fertilization laboratory. We will perform Quality Control to review how changes in temperature and setting can effect specimens

Conditions

Timeline

Start date: 2007-07-01
Primary completion: 2022-12-01
Completion: 2022-12-01
First posted: 2010-10-13
Last updated: 2023-05-03

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT01219439. Inclusion in this directory is not an endorsement.