Trials / Completed
CompletedNCT01218165
Low Grade Inflammation, Gut Microbiota and Barrier Function in Elderly Humans
The Inflammaging Network: Bridging Low Grade Inflammation With Gut Microbiota and Intestinal Barrier Function in Elderly Humans
- Status
- Completed
- Phase
- EARLY_Phase 1
- Study type
- Interventional
- Enrollment
- 48 (estimated)
- Sponsor
- Charite University, Berlin, Germany · Academic / Other
- Sex
- Male
- Age
- 65 Years – 85 Years
- Healthy volunteers
- Accepted
Summary
Cardiovascular diseases (CVD) are the main cause of death in the European Union. A large part of the aging process, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, wich results in the low grade chronic pro-inflammatory status termed inflammaging. It can contribute to a number of age-related chronic diseases (e.g. atherosclerosis, type 2 diabetes, Alzheimer disease, osteoporosis). Prevention or delay in onset of chronic diseases can potentially benefit a large segment of the elderly population. Now it is hypothesised that a probiotic drink can reduce low-grade inflammation through improvement of the gut barrier function and gut microbiota composition in elderly people with low-grade inflammation.
Detailed description
Cardiovascular diseases (CVD) are the main cause of death in the European Union. A large part of the aging process, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, wich results in the low grade chronic pro-inflammatory status termed inflammaging. It can contribute to a number of age-related chronic diseases (e.g. atherosclerosis, type 2 diabetes, Alzheimer disease, osteoporosis). Prevention or delay in onset of chronic diseases can potentially benefit a large segment of the elderly population. Now it is hypothesised that a probiotic drink can reduce low-grade inflammation through improvement of the gut barrier function and gut microbiota composition in elderly people with low-grade inflammation.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | Probiotic drink | This group receives a probiotic drink daily for 6 week. |
| OTHER | Control Group | without intervention |
Timeline
- Start date
- 2010-05-01
- Primary completion
- 2010-11-01
- Completion
- 2011-05-01
- First posted
- 2010-10-11
- Last updated
- 2011-10-28
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT01218165. Inclusion in this directory is not an endorsement.