NCT01218074

Platelets Antiaggregation Control Enhancement (PACE) Study

Platelets Antiaggregation Control Enhancement Study: an Independent Randomized Blind Prospective Study

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Cardiochirurgia E.H. · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Many patients undergo cardiac surgery without proper suspension of antiaggregation drugs. This is blamed to increase dramatically bleeding and use of allogenic blood transfusions. The investigators test the hypothesis that routine use of aggregometry could show antiaggregated patient and lead to normalization of platelet function via administration of Desmopressin thus limiting bleeding and transfusions.

Conditions

• Bleeding
• Blood Transfusion

Interventions

Type	Name	Description
DEVICE	Aggregometry+Thromboelastography	Patients undergo standard thromboelastography and subsequent aggregometry to test effectiveness of residual antiaggregation drugs. Patients found to have altered value undergo optimization with desmopressin.
DEVICE	Thromboelastography Alone	Patients undergo standard of care Thromboelastography to evaluate overall coagulation performance.

Timeline

• Start date: 2010-12-01
• Primary completion: 2016-09-01
• Completion: 2017-09-01
• First posted: 2010-10-11
• Last updated: 2018-01-26

Locations

1 site across 1 country: Italy