NCT01212874

Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery

Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass(CPB) in Cardiac Surgery: a Randomized, Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Loma Linda University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This is an investigator initiated, sponsored, open label, prospective randomized controlled trial to be performed in adult patients undergoing scheduled cardiac surgery. Patients will be randomized to esmolol infusion or nitroglycerin infusion for control of hypertension that occurs during cardiac surgery from induction of anesthesia to initiation of cardiopulmonary bypass (CPB).

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	nitroglycerin	nitroglycerin administered as an infusion following a step up/step down protocol to treat hypertension in patients undergoing cardiac surgery.
DRUG	esmolol	esmolol will be administered by infusion following a step up / step down protocol to control hypertension.

Timeline

• Start date: 2010-12-01
• Primary completion: 2014-06-01
• Completion: 2014-06-01
• First posted: 2010-10-01
• Last updated: 2019-03-01
• Results posted: 2016-08-17

Locations

1 site across 1 country: United States