NCT01206933

The Effect of HIV Tat Protein on HCV Replication in an In-vitro Model System

The Effect of HIV Tat Protein on HCV Replication in an In-vitro Model System.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: George Washington University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Investigators in the Division of Infectious Diseases and the Departments of Biochemistry and Molecular Biology of The George Washington University Medical Center are carrying out a research study to determine why patients with Human Immunodeficiency Virus (HIV) and Hepatitis C virus (HCV) co-infection (HIV/HCV) have a more rapid and progressive course of HCV infection, leading to fatty infiltration of the liver and cirrhosis.

Detailed description

Samples will be collected from 4 groups of patients with HIV/HCV infection, identified by the virologic control of either HIV, HCV, or both. Sera will be used in an in-vitro hepatocyte model of hepatitis C infection to better understand the pathogenesis of HIV/HCV co-infection, and to gain insight into intracellular mechanisms.

Conditions

• Human Immunodeficiency Virus (HIV)
• Hepatitis C, Chronic

Timeline

• Start date: 2010-07-01
• Primary completion: 2015-06-01
• Completion: 2015-06-01
• First posted: 2010-09-22
• Last updated: 2016-02-10

Locations

1 site across 1 country: United States