NCT01206452

Oral Steroids Before Pulmonary Vein Isolation to Improve Outcomes

Use of Oral Steroids Before Circumferential Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation to Improve Outcomes

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Dhanunjaya Lakkireddy, MD, FACC · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary purpose of this study is to assess the efficacy of oral prednisone in improving the outcomes of pulmonary vein isolation with radiofrequency ablation.

Detailed description

The purpose of this study is: 1. To assess the efficacy of oral prednisone in improving the outcomes of pulmonary vein isolation with radiofrequency ablation. 2. To measure the inflammatory cytokine (TNF-α, IL-1, IL-6, IL-8) response to radiofrequency ablation for atrial fibrillation with or without prior prednisone treatment.

Conditions

• Atrial Fibrillation

Interventions

Type	Name	Description
DRUG	Prednisone	60mg of oral prednisone 2 days before procedure, day of procedure, and 1 day after procedure
OTHER	Placebo	60mg placebo pill given 2 days before procedure, day of procedure, and 1 day after procedure
PROCEDURE	Ablation Procedure	Atrial Fibrillation (AF) ablation

Timeline

• Start date: 2010-09-01
• Primary completion: 2013-12-01
• Completion: 2013-12-01
• First posted: 2010-09-21
• Last updated: 2017-05-17
• Results posted: 2017-05-17

Locations

1 site across 1 country: United States