NCT01204957

Brown Seaweed as a Breast Cancer Preventive

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: University of South Carolina · Academic / Other
• Sex: Female
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Japanese postmenopausal women in Japan have about one ninth the rate of American postmenopausal women. Rates of breast cancer double even after just ten years among Japanese women who migrate to the US. Diet is thought to be an important factor, and the investigators were interested in whether dietary seaweed, with and without soy supplements, could influence known biomarkers of breast cancer risk in American women.

Detailed description

33 healthy postmenopausal women were randomized to 6 wk seaweed then 1 wk seaweed plus soy or 6 wk placebo then 1 wk placebo plus soy. Blood and urine samples were collected at the end of each treatment period and analyzed for estrogen, homocysteine, antioxidants, insulin-like growth factors and thyroid hormones. Urine was analyzed for phytoestrogens and iodine.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Seaweed and Soy Protein	5 g/d Seaweed for 6 wks, followed by 5 g/d Seaweed + Soy Protein for 1 wk
DIETARY_SUPPLEMENT	Placebo and Soy Protein	5 g/d Placebo for 6 wks, followed by 5 g/d Placebo + Soy Protein for 1 wk

Timeline

• Start date: 1998-10-01
• Primary completion: 1999-03-01
• Completion: 1999-03-01
• First posted: 2010-09-17
• Last updated: 2015-04-06

Locations

1 site across 1 country: United States