NCT01204268

The Neuroprotection of Sevoflurane Preconditioning on Intracranial Aneurysm Surgery

The Neuroprotection of Sevoflurane Preconditioning on Perioperative Ischemia-reperfusion Injury During Intracranial Aneurysm Surgery

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.

Detailed description

The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery. The patients with cerebral aneurysm will be recruited in current study. The sevoflurane preconditioning will be performed before the surgical procedure. The neurological injury biomarkers, such as S-100b and NSE will be detected. The neurological function and recovery will be assessed after the surgery.

Conditions

• Brain Ischemia

Interventions

Type	Name	Description
PROCEDURE	Sev-I group	Sevoflurane will be given before the cerebral artery clip as a preconditioning procedure for the coming ischemia-reperfusion injury.
PROCEDURE	Sevo continuous inhalation	Patients will receive the anesthesia with continuous inhalation of sevoflurane.

Timeline

• Start date: 2009-08-01
• Primary completion: 2011-08-01
• Completion: 2011-10-01
• First posted: 2010-09-17
• Last updated: 2010-09-20

Locations

1 site across 1 country: China