NCT01199094

Clinical Assessment of Patients With High Bone Mass Due to Mutation in Lrp5

Clinical Assessment of Patients With High Bone Mass Due to Mutation in Low Density Lipoprotein l Receptor 5

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 38 (actual)
• Sponsor: Odense University Hospital · Academic / Other
• Sex: All
• Age: 8 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to describe patients with a high bone mass phenotype due to a mutation in the low density lipoprotein l receptor 5 gene (LRP5) and compare them with age and sex matched controls. Moreover, bone density and microarchitecture as well as markers of bone metabolism are evaluated

Detailed description

Cases and controls are closely matched on age and sex and evaluated cross-sectionally. Dual x-ray absorptiometry (DXA) and high resolution peripheral quantitative computed tomography (HR-pQCT) are used in order to evaluate bone density as well as microarchitecture. Bone turnover markers and body composition are also measured.

Conditions

• Osteopetrosis

Timeline

• Start date: 2009-01-01
• Primary completion: 2010-04-01
• Completion: 2010-06-01
• First posted: 2010-09-10
• Last updated: 2010-09-10

Locations

1 site across 1 country: Denmark