Trials / Completed
CompletedNCT01198171
Racial and Genetic Biomarkers of Response in Tissue Samples From Patients With Endometrial Cancer
The Relationship of Racial Genetic Admixture With Endometrial Cancer Outcomes
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 243 (actual)
- Sponsor
- Gynecologic Oncology Group · Network
- Sex
- Female
- Age
- —
- Healthy volunteers
- Not accepted
Summary
This research study is studying racial and genetic biomarkers of response in tissue samples from patients with endometrial cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. DNA analysis of tumor tissue may also help doctors predict how well patients will respond to treatment.
Detailed description
PRIMARY OBJECTIVES: I. To identify racial categorization as the proportion of genetic background of African-American or European-American women with endometrioid endometrial cancer (EEC). II. To evaluate the association of racial genetic admixture with clinicopathologic variables and outcomes. SECONDARY OBJECTIVES: I. To compare the concordance between racial genetic admixture and self-designated race categorization. OUTLINE: This is a multicenter study. Patients are stratified by race (African-American vs European-American) and disease stage (I vs II vs III vs IV). DNA from archived frozen normal tissue samples is genotyped for the ancestry informative markers. Clinicopathological and demographic characteristics associated with each sample are also collected.
Conditions
- Stage I Uterine Corpus Cancer
- Stage II Uterine Corpus Cancer
- Stage III Uterine Corpus Cancer
- Stage IV Uterine Corpus Cancer
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Laboratory Biomarker Analysis | Correlative studies |
| OTHER | Study of Socioeconomic and Demographic Variables |
Timeline
- Start date
- 2010-01-01
- Primary completion
- 2017-02-01
- Completion
- 2017-02-01
- First posted
- 2010-09-09
- Last updated
- 2024-08-14
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT01198171. Inclusion in this directory is not an endorsement.