NCT01196845

Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome

Inflammation and Oxidative Stress of Adipose Tissue in Obese and Non-obese Patients Having Sleep Apnea Syndrome

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University Hospital, Grenoble · Academic / Other
• Sex: Male
• Age: 18 Years – 69 Years
• Healthy volunteers: Not accepted

Summary

The main objective of this study is to evaluate the decrease of inflammation of adipose tissue in obese and non-obese patients having a sleep apnea syndrome and treated or not by continuous positive airway pressure (cPAP). An interim analysis will be performed when 40 patients will be included.

Detailed description

Inflammation of adipose tissue will be evaluated by RT-PCR on mRNA of pro and anti-inflammatory cytokines (IL-1, IL-6, IL-4, IL-10, IL-12, RANTES, TNFa, leptin, adiponectin, CD68).

Conditions

• Decrease of Inflammation of Adipose Tissue
• Sleep Apnea Syndrome

Interventions

Type	Name	Description
DEVICE	cPAP	Patients are randomised in 2 arms : cPAP or sham cPAP
DEVICE	cPAP	Patients are randomised in 2 arms : cPAP or Sham cPAP
DEVICE	cPAP	Patients are randomised in 2 arms : cPAP or sham cPAP
DEVICE	cPAP	Patients are randomised in 2 arms : cPAP or sham cPAP

Timeline

• Start date: 2010-10-16
• Primary completion: 2017-02-16
• Completion: 2017-02-16
• First posted: 2010-09-09
• Last updated: 2025-12-29

Locations

1 site across 1 country: France