NCT01195064

Endothelial Function Study Before Cardiovascular Surgery

Endothelial Function Study Before Cardiovascular Surgery in COPD and/or SAS Patients

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 109 (actual)
• Sponsor: University Hospital, Grenoble · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The aim of this clinical trial is to evaluate the effect of chronic obstructive pulmonary disease (COPD) and/or obstructive sleep apnea syndrome (OSAS) on the endothelial function, before cardiovascular surgery, compared to non COPD non OSAS patients undergoing also a cardiovascular surgery, by an observational physiological study. An interim analysis will be performed when 100 patients will be included.

Detailed description

Secondary objectives of this clinical trial : * To evaluate the effect of COPD and/or OSAS on the systemic inflammation, insulin-resistance and oxydative stress, in comparison with non COPD non OSAS patients. * To evaluate the effect of COPD and/or OSAS on the inflammation and oxydative stress of the adipose tissue, in comparison with non COPD non OSAS patients. * To validate the STOP-BANG questionnaire in patients undergoing a cardiovascular surgery

Conditions

• Chronic Obstructive Pulmonary Disease (COPD)
• Obstructive Sleep Apnea Syndrome (OSAS)

Timeline

• Start date: 2010-04-01
• Primary completion: 2018-11-30
• Completion: 2018-11-30
• First posted: 2010-09-03
• Last updated: 2022-09-27

Locations

3 sites across 1 country: France