NCT01194895

A Trial to Evaluate the Impact of Lung-protective Intervention in Patients Undergoing Esophageal Cancer Surgery

Impact of Intraoperative Protective One-lung Ventilation in Patients Undergoing Esophagectomy : a Prospective Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 101 (actual)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this trial is to determine whether low tidal volume during intraoperative one-lung ventilation could decrease the incidence rate of postoperative acute lung injury compared to "normal" tidal volume.

Detailed description

Large tidal volume are known risk factor of acute lung injury.Mechanical ventilation with low tidal volume has been shown to attenuate lung injuries in critically ill patients.Esophagectomy surgery need a relatively long time of one-lung ventilation. A normal tidal volume of two-lung ventilation should be a large one when exerted to one lung. We hypothesized that low tidal volume ventilation during one-lung ventilation could decrease incidence rate of postoperative acute lung injury and mortality.

Conditions

• Acute Lung Injury

Interventions

Type	Name	Description
OTHER	protective ventilation	set tidal volume of 5ml/kg during one-lung ventilation
OTHER	conventional ventilation	keep tidal volume at 8ml/kg during one-lung ventilation

Timeline

• Start date: 2010-08-01
• Primary completion: 2013-01-01
• Completion: 2013-03-01
• First posted: 2010-09-03
• Last updated: 2013-03-14

Locations

1 site across 1 country: China