NCT01192386

Eosinophil Markers and Development of Disease in Allergic Rhinitis

Eosinophil Markers and Development of Disease in Allergic Rhinitis. A 15-year Follow-up of Patients With Grass Pollen Induced Hayfever.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 29 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Inflammatory proteins from eosinophil granulocytes in blood from patients with seasonal allergic hayfever have been shown to predict development of asthma at a six-year follow-up. This study is a 15-year follow-up of the same patients to verify earlier results and study disease development.

Detailed description

The study consists of a single visit at which patients fill in a questionnaire on actual hayfever and asthma symptoms as well as current treatment. Blood samples and nasal lavages are drawn and analysed for eosinophils as well as eosinophil cationic protein and tryptase. Spirometry is performed. If patients use drugs which can interfere with results, ie. corticosteroids or beta-agonists, biochemistry and/or spirometry are omitted.

Conditions

• Seasonal Allergic Rhinitis

Timeline

• Start date: 2010-05-01
• Primary completion: 2010-05-01
• Completion: 2010-05-01
• First posted: 2010-09-01
• Last updated: 2010-09-01