Trials / Completed
CompletedNCT01190345
Anti Cancer Stem Cell Activity of Pre-operative Bevacizumab and Chemotherapy in Breast Cancer
Phase II" Proof of Concept " Trial Evaluating Anti Cancer Stem Cell Activity of Pre-operative Bevacizumab in Combination With Chemotherapy in Breast Cancer
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 75 (estimated)
- Sponsor
- Institut Paoli-Calmettes · Academic / Other
- Sex
- Female
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to evaluate anti-cancer stem cell (CSC) activity (measured by the amount of Aldehyde dehydrogenase 1/ALDH1+ cells before and after treatment) of pre-operative bevacizumab in combination with conventional chemotherapy in breast cancer receiving neo-adjuvant treatment, compared to a control arm receiving chemotherapy alone.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | bevacizumab | Patients receive on day 1 of each cycle : bevacizumab 15 mg/kg (8 injections in total). |
| DRUG | no bevacizumab | no bevacizumab |
Timeline
- Start date
- 2010-05-01
- Primary completion
- 2012-07-24
- Completion
- 2017-10-06
- First posted
- 2010-08-27
- Last updated
- 2018-08-13
Locations
3 sites across 1 country: France
Source: ClinicalTrials.gov record NCT01190345. Inclusion in this directory is not an endorsement.