NCT01186289

Statin Therapy To Limit Cognitive Dysfunction After Cardiac Surgery

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

The primary aim of our prospective, randomized, double-blind interventional clinical trial is to determine the effectiveness of high dose atorvastatin therapy to reduce post operative cognitive dysfunction (POCD) in patients undergoing cardiac valve surgery. We hypothesize that therapy with high dose atorvastatin will significantly reduce the incidence and/or severity of POCD.

Conditions

• Neurocognitive Dysfunction

Interventions

Type	Name	Description
DRUG	atorvastatin	high dose atorvastatin therapy (80 mg/day) beginning 48 to 72-hours preoperatively and continuing until 6-weeks postoperatively

Timeline

• Start date: 2010-10-01
• Primary completion: 2011-10-01
• Completion: 2012-10-01
• First posted: 2010-08-23
• Last updated: 2015-10-14

Locations

1 site across 1 country: United States