Trials / Completed
CompletedNCT01185925
Exercise Oscillatory Breathing and Sildenafil in Heart Failure
PDE5-Inhibition With Sildenafil Reverses Exercise Oscillatory Breathing in Chronic Heart Failure: a Long-Term Cardiopulmonary Exercise Testing Placebo-Controlled Study
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 32 (actual)
- Sponsor
- University of Milan · Academic / Other
- Sex
- Male
- Age
- 30 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
Exercise oscillatory breathing (EOB) is a ventilatory abnormality that occurs in approximately 20% of heart failure (HF) patients and carries a very unfavourable prognosis. Pathophysiology seems quite complex and putative mechanisms include increased pulmonary capillary pressure and pulmonary vasoconstriction, circulatory blood-flow fluctuations in the pulmonary arterial system and instability of ventilatory control. Inhibition of the phosphodiesterase 5 (PDE5) isoenzyme favourably regulates pulmonary vascular tone and permeability through over signaling of the endothelial nitric oxide pathway. The investigators tested the hypothesis that sildenafil would reverse the EOB pattern in patients with HF and pulmonary hypertension.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Sildenafil | Sildenafil, 50 mg 3 times/day |
| DRUG | Placebo | Placebo |
Timeline
- Start date
- 2008-04-01
- Primary completion
- 2009-12-01
- Completion
- 2010-06-01
- First posted
- 2010-08-20
- Last updated
- 2011-08-05
Source: ClinicalTrials.gov record NCT01185925. Inclusion in this directory is not an endorsement.