NCT01185132

Intensity Modulated Radiotherapy (IMRT) vs. 3D-conformal Accelerated Partial Breast Irradiation (APBI) for Early Stage Breast Cancer After Lumpectomy

A Phase III Randomized Study Comparing Intensity Modulated Planning Versus 3-Dimensional Planning for Accelerated Partial Breast Radiotherapy

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 660 (estimated)
• Sponsor: Rocky Mountain Cancer Centers · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

In the setting of radiotherapy as part of breast-conservation therapy for patients with early stage breast cancer, the novel planning and delivery method of intensity modulated radiotherapy is an effective and safe alternative to the commonly-used standard 3D-conformal external beam radiotherapy, spares more normal breast and lung tissue, and may lead to improved clinical outcomes.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
RADIATION	accelerated partial breast irradiation - 3D-conformal planning	38.5 Gy, 10 fractions over 5 days
RADIATION	accelerated partial breast irradiation - IMRT planning	38.5 Gy, 10 fractions over 5 days

Timeline

• Start date: 2009-07-01
• Primary completion: 2018-07-01
• Completion: 2028-07-01
• First posted: 2010-08-19
• Last updated: 2014-06-26

Locations

5 sites across 1 country: United States