NCT01184430

Effect of Perioperative Hemodynamic Optimization on the Immune Function Parameters of Peripheral Blood Monocytes After Cardiac Surgery

Monocentric Pilot Study of Effect of Perioperative Hemodynamic Optimization on the Immune Function Parameters of Peripheral Blood Monocytes After Cardiac Surgery

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cardiac surgery patients have a high risk to suffer from postoperative infections. Some studies have shown, that humoral and cellular factors are associated with perioperative immunodysfunction and can increase the risk of postoperative infections. Monocytes in the blood and, especially alveolar macrophages are important for an adequate host defence. In studies the investigators have shown that hemodynamic parameters have a significant influence on the probability to develop postoperative infections. The aim of the study is to investigate, whether cardiac surgery patients have an altered immune function after surgery that is predictive for the latter development of subsequent infections and whether they benefit from a goal-directed volume and hemodynamic therapy.

Conditions

• Postoperative Wound Infection
• Postoperative Outcome

Interventions

Type	Name	Description
DEVICE	Pulse contour cardiac output device	Goal directed volume therapy using stroke volume variation and cardiac output to guide volume therapy and inotropic support.

Timeline

• Start date: 2013-08-01
• Primary completion: 2014-03-01
• Completion: 2014-12-01
• First posted: 2010-08-19
• Last updated: 2013-08-12

Locations

1 site across 1 country: Germany