NCT01181414

Spanish Atrial Fibrillation And Resynchronization Study

Phase 4. Study of Cardiac Resynchronization Therapy in Patients With Permanent Atrial Fibrillation.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Hospital Clinic of Barcelona · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the present study is to compare the response to cardiac resynchronization therapy (CRT) in patients with chronic advanced heart failure and permanent atrial fibrillation (AF) depending on atrio ventricular junction (AVJ) is ablated or not.

Detailed description

Cardiac resynchronization therapy (CRT) improves the functional capacity and the quality of life and reduces the mortality of patients with dilated cardiomyopathy, low ejection fraction and wide QRS. Only 2% of patients included in CRT randomized trials were in AF. To obtain a good response to CRT, percentage \>90% of ventricular pacing must be obtained. Based on observational studies, current guidelines of CRT recommend the atrio ventricular junction (AVJ) ablation in those patients with permanent atrial fibrillation.

Conditions

• Chronic Heart Failure
• Cardiomyopathy, Dilated
• Atrial Fibrillation

Interventions

Type	Name	Description
PROCEDURE	Atrio ventricular junction ablation with radio-frequency	Atrioventricular junction ablation by using radiofrequency energy.
DRUG	Beta blocker/digoxine/amiodarone	Ventricular rate control by using drug treatment.

Timeline

• Start date: 2010-10-01
• Primary completion: 2014-11-01
• Completion: 2015-01-01
• First posted: 2010-08-13
• Last updated: 2015-03-10

Locations

1 site across 1 country: Spain