Trials / Completed
CompletedNCT01180478
Comparison Study of Narrow Band Imaging Versus White Light Resection in Patients With Bladder Tumors/Cancer
A Multi-center, International Study to Compare Use of Narrow Band Imaging (NBI) Versus White Light(WL) During Transurethral Resection of Bladder Tumors (TURB) to Asses Recurrence of Bladder Cancer in Terms of Safety and Efficacy
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 965 (actual)
- Sponsor
- Clinical Research Office of the Endourological Society · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to compare the recurrence rate at 1 year following Narrow Band Imaging and trans-urethral resection of bladder tumor with White Light and TURB in patients with non-muscle invasive bladder cancer.
Detailed description
Currently bladder tumors are diagnosed visually with standard cystoscopy that uses white light, or light that is generated encompassing the entire visual spectrum. Some tumors such as carcinoma in situ may not be visible using white light and require patients to undergo random bladder biopsies in order to find the cancer. Recently the development of photodynamic agents have been shown to enhance these procedures to accomplish better resection and identify over-looked tumors. However, these methods often require the instillation of dyes into the bladder as well as specialized cystoscopes. Narrow band imaging (NBI) is now available which uses a special filter to limit the light to only certain wavelengths which allows the identification of areas of increased vascularity or abnormalities without the need for dyes. NBI has been investigated in gastro-intestinal disease and found to be beneficial. Early reports in urology suggest that this technology may reduce the number of tumors that are missed which could impact the recurrence rate of bladder tumors, but this is not known at this time.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | White Light | White Light Cystoscopy |
| DEVICE | Narrow Band Imaging | Narrow Band Imaging |
Timeline
- Start date
- 2010-08-01
- Primary completion
- 2013-11-01
- Completion
- 2013-11-01
- First posted
- 2010-08-12
- Last updated
- 2018-04-25
- Results posted
- 2018-04-25
Source: ClinicalTrials.gov record NCT01180478. Inclusion in this directory is not an endorsement.