NCT01180192

Postpartum Oxygen Inhalation for the Treatment of Postpartum Haemorrhage

Phase 3 Study of Postpartum Oxygen Inhalation for the Treatment of Postpartum Haemorrhage

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 450 (estimated)
• Sponsor: Erzincan Military Hospital · Academic / Other
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

In the aetiology of postpartum uterine atony, hypoxia is considered an important factor although some suggest that peripheral oxygen saturation is not influenced by oxygen inhalation in women during the first and second stages of labor. Enhancing oxygen delivery to myometrium through additional inhaled oxygen may improve uterine contractions. Therefore, it is reasonable to consider that oxygen inhalation may promote myometrial contraction and prevent postpartum haemorrhage (PPH) due to uterine atony. The tendency for the uterus to relax in women encountering respiratory problems immediately after cesarean section under general anaesthesia further strengthened this theory. The aim of this study was to evaluate the effectiveness of oxygen inhalation immediately after vaginal delivery on blood loss. The investigators hypothesized that inhaled oxygen helps to maintain uterine retraction during immediate postpartum period and hence reduces vaginal blood loss.

Conditions

• Postpartum Hemorrhage

Interventions

Type	Name	Description
DRUG	oxygen	either 8 L/minute O2 via face mask for 2 hours

Timeline

• Start date: 2010-05-01
• Primary completion: 2010-05-01
• Completion: 2010-09-01
• First posted: 2010-08-12
• Last updated: 2011-02-14

Locations

1 site across 1 country: Turkey (Türkiye)