NCT01176760

Intact Vagal Innervation for and Glucagon-like Peptide-1 (GLP-1) Effects

The Significances of Intact Vagal Innervation for the Glucose and GLP1 Induced Insulin Secretion

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to investigate the role of transmission via the vagal nerve for the effect of glucose and Glucagon-like peptide-1 (GLP-1) in respect to insulin secretion. The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the investigators will research individuals with and without intact nervous supply.

Detailed description

GLP-1 is a potent enterogastron and incretin hormone. It is rapidly inactivated by dipeptidyl peptidase IV so only 10-15% enters the systemic circulation. This has led to the hypothesis that GLP-1 interact locally with afferent sensory nerve fibers. We investigated the role of intact vagal innervations on the effect of glucose and GLP-1 on the insulin secretion

Conditions

• Vagotomy, Truncal

Interventions

Type	Name	Description
DRUG	Dipeptidyl peptidase 4 (DPP 4) inhibitor	One tablet (50 mg)of DPP4 inhibitor is to be taken 12 and 1 hours before start of the oral glucose tolerance test (50 g glucose and 1.5 g paracetamol dissolved in 300 ml water)on day 3
OTHER	oral glucose	50 g glucose dissolved in 300 ml water with 1,5 g paracetamol is to be ingested orally within the first 15 minutes.

Timeline

• Start date: 2009-08-01
• Primary completion: 2011-10-01
• Completion: 2012-12-01
• First posted: 2010-08-06
• Last updated: 2012-12-07

Locations

1 site across 1 country: Denmark