NCT01174602

Inpatient Exposure Therapy and Response Prevention & Cognitive Remediation Therapy for Anorexia Nervosa

Randomized Controlled Trial of Inpatient Exposure Therapy and Response Prevention for Anorexia Nervosa

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: New York State Psychiatric Institute · Academic / Other
• Sex: All
• Age: 16 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Exposure and response prevention (AN-EXRP) will help individuals with anorexia nervosa improve their eating behavior.

Detailed description

Anorexia nervosa (AN) is a serious illness associated with substantial morbidity and a mortality rate among the highest of any psychiatric illness. The rate of relapse is disturbingly high, with up to 50% of patients requiring re-hospitalization within a year of discharge. Current treatments are inadequate in helping older adolescents and adults achieve sustained recovery. Importantly, eating behavior remains disturbed after weight restoration: patients demonstrate restrictive eating in their self-selected foods and in standardized meals, and caloric intake in standardized meals is inversely related to pre-meal anxiety. Emerging data suggest that eating behavior is particularly important in post-hospital course, and that significantly altering eating behavior is critical in improving outcome for these individuals. Furthermore, caloric intake in standardized meals has been shown to be related to pre-meal anxiety. This study evaluates the potential utility of two psychotherapeutic interventions in improving eating behavior prior to hospital discharge. Each individual receives, in random order, Cognitive Remediation Therapy for 4 weeks and Exposure and Response Prevention for AN for 4 weeks. The investigators hypothesize that these interventions will lead to improvement in eating behavior, measured by food diaries and standardized meals.

Conditions

• Anorexia Nervosa

Interventions

Type	Name	Description
BEHAVIORAL	Exposure Therapy for AN (AN-EX/RP)	12 Sessions, 3 times per week. 90 minute sessions. Group therapy twice per week.
BEHAVIORAL	Cognitive Remediation Therapy	12 Sessions, 3 times per week. 45 minute sessions. Group therapy twice per week.

Timeline

• Start date: 2009-11-01
• Primary completion: 2011-10-01
• Completion: 2014-10-01
• First posted: 2010-08-03
• Last updated: 2015-01-29

Locations

1 site across 1 country: United States