Trials / Completed
CompletedNCT01172639
Effectiveness in Daily Practice of Different Treatment Strategies for Early Rheumatoid Arthritis.
A 2 Year Prospective Multicentre Randomised Controlled Trial Comparing Effectiveness in Daily Practice of Different Treatment Strategies for Early Rheumatoid Arthritis.
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 400 (actual)
- Sponsor
- P. Verschueren · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The Combinatietherapie Bij Reumatoide Artritis (CoBRA) trial was a milestone in the development of the present treatment paradigm for Rheumatoid Arthritis (RA). This study introduced the principle of fast remission induction by means of a combination of standard Disease Modifying AntiRheumatic Drugs (DMARDs) and a step down bridge therapy with high dose glucocorticoids in early Rheumatoid Arthritis. The purpose of the present study is to compare different combinations of traditional DMARDs and glucocorticoids, based on the original CoBRA protocol, for treatment of early Rheumatoid Arthritis. Besides the efficacy and effectiveness of these strategies, patient centered outcomes and potential implementation problems of such treatment strategies are evaluated.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Methotrexate | Methotrexate tablet |
| DRUG | Sulfasalazine | Sulfasalazine tablet |
| DRUG | Leflunomide | Leflunomide tablet |
| DRUG | Prednisone | Prednisone tablet |
Timeline
- Start date
- 2009-02-01
- Primary completion
- 2015-06-01
- Completion
- 2015-06-01
- First posted
- 2010-07-30
- Last updated
- 2019-01-22
- Results posted
- 2018-12-10
Locations
17 sites across 1 country: Belgium
Source: ClinicalTrials.gov record NCT01172639. Inclusion in this directory is not an endorsement.