NCT01171365

Small Particle Steroids in Refractory Asthma

Small Particle Inhaled Steroids in Refractory Steroid-responsive Asthma

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University of Nottingham · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether an inhaled steroid with a small particle size can be an additional treatment option in patients with refractory eosinophilic asthma.

Detailed description

We have identified a group of patients with refractory asthma who have ongoing eosinophilic airway inflammation despite high dose inhaled corticosteroids. Traditional inhaled steroids have a relatively proximal airway distribution which may lead to inadequate treatment of the distal airways. We aim to demonstrate that a steroid inhaler with a smaller particle size which targets the distal airways can be a useful additional treatment option in this group of patients.

Conditions

• Asthma

Interventions

Type	Name	Description
DRUG	Ciclesonide	Inhaled ciclesonide 320mcg twice daily
DRUG	Placebo	Matched placebo inhaler two inhalations twice daily

Timeline

• Start date: 2010-01-01
• Primary completion: 2013-10-01
• Completion: 2013-12-01
• First posted: 2010-07-28
• Last updated: 2014-01-31

Locations

2 sites across 1 country: United Kingdom