NCT01170377

Effect of Valproate on Propofol

The Effect of Valproate on the Required Dose of Propofol for Sedation in Patients With Mental Retardation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Okayama University · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the effect of valproate on the required dose of propofol for sedation in patients with mental retardation.

Detailed description

The intravenous sedation with propofol is very useful for patients with mental retardation and challenging behavior. However, it is very difficult to titrate the dose of propofol for maintaining the adequate sedation depth because of the difficulty of verbal communication with them. Most of them have a epilepsy and take antiepileptic drugs. Antiepileptic drugs are thought to influence on the effect of anesthetics. Valproate is reported to inhibit the metabolism of propofol. Therefore, we divide the patients into two groups : patients receiving valproate (valproate group), patients receiving no antiepileptic drugs (control group), and compare the required dose of propofol and the recovery time.

Conditions

• Mental Retardation

Timeline

• Start date: 2007-04-01
• Primary completion: 2010-08-01
• Completion: 2010-08-01
• First posted: 2010-07-27
• Last updated: 2015-10-21

Locations

1 site across 1 country: Japan