NCT01169467

Cerebral Perfusion Pressure Using Precedex and Other Sedatives

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 89 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the effects of using dexmedetomidine (Precedex) in addition to the current standard-of-care for sedation.

Detailed description

Primarily, this study seeks to explore whether there is a difference in mean arterial pressure (MAP) variability, incidence of intracranial hypertension, intracranial pressure (ICP) variability, cerebral perfusion pressure (CPP) and Cerebrovascular pressure reactivity index (PRx) in two groups of subjects. Patients must be submitted to the ICU and be endotracheally intubated and receiving mechanical ventilation with continuous IV sedation for less than 24 hours after recruitment into the study.

Conditions

• Endotracheal Intubation
• Continuous IV Sedation
• ICP Monitoring

Interventions

Type	Name	Description
DRUG	Standard-of-Care plus Dexmedetomidine	Subjects who are treated with dexmedetomidine (Precedex) in addition to the standard of care sedation regiment
OTHER	Standard-of-Care	Subjects who are treated with the standard of care sedation regiment only.

Timeline

• Start date: 2009-10-01
• Primary completion: 2013-11-01
• Completion: 2013-11-01
• First posted: 2010-07-26
• Last updated: 2015-11-02
• Results posted: 2015-11-02

Locations

1 site across 1 country: United States