NCT01169389

Analgesic Control Following Knee Arthroscopy

Analgesic Control Following Knee Arthroscopy: Results of a Randomised , Double-blinded Trial Comparing a Hyaluronic Acid Supplement to Bupivacaine

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 98 (actual)
• Sponsor: Orthopaedic Research and Innovation Foundation, Ireland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate the analgesic effects offered by bupivacaine and Durolane (a hyaluronic acid supplement) administered immediately following the completion of knee arthroscopy.

Detailed description

There is increasing evidence of the toxic effects of intraarticular administration of local anaesthetic. Hyaluronic acid supplementation given at the time of knee arthroscopy has not been fully evaluated as a possible alternative. We have studied the efficacy of a hyaluronic acid (HA) supplement (Durolane®) and a local anaesthetic (Bupivacaine) at providing early and short-term post-operative analgesic control following knee arthroscopy.Patients will be randomised to receive either 10mls of 0.5% Bupivacaine or 10mls of Durolane® into the joint immediately after completion of surgery. WOMAC and Tegner-Lysholm scores were obtained at baseline then at 1, 2, and 6-weeks post surgery. VAS pain scores were obtained at baseline; 1 and 24-hours; and 1, 2 and 6 weeks following surgery.

Conditions

• Knee
• Arthroscopy
• Analgesia

Interventions

Type	Name	Description
PROCEDURE	Intraarticular injection	Durolane, one vial
PROCEDURE	Intra-articular injection of 0.5% Bupivacaine

Timeline

• Start date: 2009-01-01
• Primary completion: 2009-04-01
• Completion: 2009-06-01
• First posted: 2010-07-26
• Last updated: 2010-07-30

Locations

1 site across 1 country: Ireland