NCT01169038

Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Sarcoidosis is a granulomatous disease for which the molecular and immunologic association with mycobacteria continues to strengthen. The investigators are interested in conducting a proof-of-concept investigation of the effects of antibiotics on sarcoidosis resolution. The investigators hypothesize that pulmonary sarcoidosis will improve faster if patients are given antimycobacterial therapy, in addition to their standard therapy.

Conditions

• Pulmonary Sarcoidosis
• Lung Function

Interventions

Type	Name	Description
DRUG	levaquin; ethambutol; rifampin and azithromycin.	Levaquin 750 mg loading on day 1, then 500 mg po QD Ethambutol 15-25 mg/kg for a maximum of 1200mg po QD Azithromycin 500mg on day 1, then 250 mg po QD \*\*Rifampin 10 mg/kg for a maximum of 600mg po QD or Rifabutin 10 mg/kg for a maximum of 300 mg po QD. \*\*We will not use both, but either one or the other based upon if the patient is on other medications that are metabolized by the cytochrome P450 pathway.

Timeline

• Start date: 2010-07-01
• Primary completion: 2010-11-01
• Completion: 2010-11-01
• First posted: 2010-07-23
• Last updated: 2012-10-31
• Results posted: 2012-10-19

Locations

1 site across 1 country: United States