NCT01167283

Effect of Electrostimulation in Chronic Obstructive Pulmonary Disease (COPD)

Effect of Electromyostimulation in Severe Chronic Obstructive Pulmonary Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France · Other Government
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study was designed to test the following hypothesis: To investigate whether COPD muscles can respond to stimuli in terms of changes in fiber-type distribution.

Detailed description

Background: Muscle dysfunction is a major problem in chronic obstructive pulmonary disease (COPD). It is characterized by muscle fiber-type redistribution and oxidative stress. Classical training does not improve these features. Objectives: To investigate whether electrostimulation program following exacerbation can modify muscle structure and function in COPD patients. Method: We propose to conduct a controlled and randomized clinical trial comparing the efficacy of muscle electrostimulation training of the lower limbs to sham training in 15 patients with COPD. Patients are included in either 6 weeks of electrostimulation training (active treatment group) or 6 weeks of sham electrostimulation. Primary outcomes were changes in muscle structure, muscle oxidative stress and their relationship with quadriceps force and exercise tolerance.

Conditions

• Chronic Obstructive Pulmonary Disease

Interventions

Type	Name	Description
DEVICE	Electrostimulation	Electrostimulation: 35 Hz, 0.4 ms, 1 h; 5 times/week
DEVICE	Sham stimulation	Sham stimulation: 1 h; 5 times/week

Timeline

• Start date: 2006-07-01
• Primary completion: 2010-04-01
• Completion: 2010-04-01
• First posted: 2010-07-22
• Last updated: 2010-08-06