NCT01163214

Management of Postoperative Pain After Total Knee Replacement.

Prospective Randomized Study Comparing Regional Anesthetic Blocks and Periarticular Infiltration for the Management of Postoperative Pain After Total Knee Replacement.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 160 (actual)
• Sponsor: Mark J. Spangehl, M.D. · Academic / Other
• Sex: All
• Age: 18 Years – 79 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare two methods of postoperative pain management in patients undergoing total knee replacement.

Detailed description

Patients undergoing total knee replacement will be assigned at random to receive one of two methods of postoperative pain management. Patients assigned to nerve block will receive regional anesthetic nerve block using an indwelling femoral nerve catheter and a single shot sciatic nerve block. Patients assigned to periarticular injection will receive periarticular local injection into the periarticular soft tissues at the time of knee replacement using a combination of ropivacaine, epinephrine, ketorolac, and morphine sulphate. Additionally, all patients will be given a standardized combination of oral analgesic medications preoperatively and postoperatively. All patients will receive a posterior stabilized total knee replacement through an medial parapatellar approach.

Conditions

• Postoperative Pain
• Knee Replacement Arthroplasty

Interventions

Type	Name	Description
DRUG	Nerve Block	Regional anesthetic nerve block using an indwelling femoral nerve catheter and a single shot sciatic nerve block using 0.5% ropivacaine.
DRUG	Periarticular Injection	Periarticular local injection into the periarticular soft tissues at the time of knee replacement using a combination of ropivacaine, epinephrine, ketorolac, and morphine sulphate. Subjects in this arm received the injection combination based on three subject weight categories.

Timeline

• Start date: 2010-07-01
• Primary completion: 2013-06-01
• Completion: 2013-06-01
• First posted: 2010-07-15
• Last updated: 2014-11-05
• Results posted: 2014-11-05

Locations

1 site across 1 country: United States