NCT01161992

Genomics of Primary Sclerosing Cholangitis (PSC)

P.R.O.G.R.E.S.S.: PSC Resource Of Genetic Risk, Environment and Synergy Studies.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,500 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 5 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Primary Sclerosing Cholangitis (PSC) is a progressive liver disorder of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PSC. This study is being done to investigate whether genes make people more likely to develop PSC. Discovery of these genes will help us to better understand how PSC developes and subsequently, to apply new approaches for its prevention, diagnosis and treatment.

Conditions

• Primary Sclerosing Cholangitis (PSC)

Interventions

Type	Name	Description
GENETIC	Genetic Analysis	Perform Genome Wide Association Studies.

Timeline

• Start date: 2002-03-01
• Primary completion: 2025-07-01
• Completion: 2025-07-31
• First posted: 2010-07-14
• Last updated: 2025-08-07

Locations

1 site across 1 country: United States