NCT01161953

Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)

Understanding the Genetic Predisposition to the Development of Primary Biliary Cirrhosis (PBC).

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,500 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Primary Biliary Cirrhosis (PBC) is a progressive liver disorder of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PBC. This study is being done to investigate whether genes make people more likely to develop PBC. Discovery of these proposed genes will help us better understand how PBC developes, and subsequently, to apply new approaches for its prevention, diagnosis and treatment.

Conditions

• Primary Biliary Cirrhosis

Interventions

Type	Name	Description
GENETIC	Genetic Analysis	Perform Genome Wide Association Studies.

Timeline

• Start date: 2002-03-01
• Primary completion: 2025-07-31
• Completion: 2025-07-31
• First posted: 2010-07-14
• Last updated: 2025-09-29

Locations

1 site across 1 country: United States