NCT01160627

Prevention of Contrast-induced Nephropathy in Patients With Acute Myocardial Infarction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 720 (actual)
• Sponsor: Odense University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

OBJECTIVE: To evaluate the efficacy of prevention of contrast induced nephropathy in patients with ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention. DESIGN: Prospective study. SETTING: Three-center study Acute kidney injury was defined as a rise in creatinine \>25% from baseline Serum creatinine will be measured at baseline and each day for the following 3 days and at 30 days. Patients will be randomised to: 1. Standard treatment 2. Standard treatment + acetylcystein for 2 days 3. Standard treatment + Sodium bicarbonate 500 ml / followed by 100 ml/h for 5 hours 4. Standard treatment + acetylcystein for 2 days + Sodium bicarbonate 500 ml / followed by 100 ml/h for 5 hours

Conditions

• Contrast Induced Nephropathy

Interventions

Type	Name	Description
OTHER	Hydration	Saline hydration
DRUG	Acetylcysteine	Acetylcystein tablets for 2 days
DRUG	Sodium bicarbonate	Sodium bicarbonate 500 ml followed by 100 ml/hour for 5 hours
DRUG	Combined Acetylcystein and Sodium Bicarbonate	Sodium bicarbonate 500 ml followed by 100 ml/hour for 5 hours combined with acetylcystein tablets for 2 days

Timeline

• Start date: 2010-04-01
• Primary completion: 2013-03-01
• Completion: 2013-03-01
• First posted: 2010-07-12
• Last updated: 2013-03-22

Locations

1 site across 1 country: Denmark