NCT01155154

Antibiotic Prophylaxis for Simple Hand Lacerations

Antibiotic Prophylaxis for Prevention of Infection in Emergency Department Patients With Simple Hand Lacerations

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 73 (actual)
• Sponsor: State University of New York - Downstate Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Research Question: In emergency department patients with simple hand cuts, do prophylactic antibiotics reduce the risk of wound infections?

Detailed description

Simple hand lacerations, defined as hand lacerations that do not involve special structures such as bones, tendons, vessels, or nerves, are common in the emergency departments. The exact rate of infection in such wounds is unclear. It is also not clear whether prescribing prophylactic antibiotics reduces the risk of infection in simple hand lacerations. The objective of this randomized double blind controlled study is to: 1. Identify the rate of infection in simple hand lacerations, 2. Identify factors or wound characteristics that increase the risk of infection, and 3. Assess whether prescribing prophylactic antibiotics decreases the risk of infections in such wounds compared to placebo.

Conditions

• Simple Hand Lacerations

Interventions

Type	Name	Description
DRUG	cephalexin	500 mg (two 250 mg capsules) every 6 hours for 7 days
DRUG	clindamycin	300 mg of clindamycin (two 150 mg capsules) every 6 hours for 7 days
DRUG	placebo	Two placebo capsules every 6 hours for 7 days

Timeline

• Start date: 2010-02-01
• Primary completion: 2012-02-01
• Completion: 2012-02-01
• First posted: 2010-07-01
• Last updated: 2014-11-07
• Results posted: 2014-11-04

Locations

3 sites across 1 country: United States