NCT01153581

Sex Hormones and Orthostatic Tolerance

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 109 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: Female
• Age: 18 Years – 34 Years
• Healthy volunteers: Accepted

Summary

This study is designed to determine the causes of "orthostatic intolerance" which occurs more commonly in women than in men. Orthostatic tolerance is the ability to remain standing up right for long periods of time, or to avoid dizziness when moving to standing from a seated or lying position.

Detailed description

In this study we are interested in determining the impact of female reproductive hormones (estrogen and progesterone) on orthostatic tolerance (described above) so we administer these hormones to participants. We also test participants' orthostatic tolerance in our laboratory and use this information to place subjects into groups.

Conditions

• Orthostatic Intolerance

Interventions

Type	Name	Description
DRUG	Ganirelix acetate	Ganirelix acetate: .25 ml/day by subcutaneous injection
DRUG	17β-Oestradiol	17 beta estradiol: 0.2 mg/day (patches)
DRUG	Progesterone	progesterone, 200 mg day-1 oral

Timeline

• Start date: 2006-02-01
• Primary completion: 2012-12-01
• Completion: 2013-05-01
• First posted: 2010-06-30
• Last updated: 2018-12-13
• Results posted: 2017-01-30

Locations

1 site across 1 country: United States