NCT01150526

Efficacy of a New Delivery System for Beta-hydroxy-beta-methylbutyrate

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 41 (actual)
• Sponsor: Metabolic Technologies Inc. · Industry
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The proposed study will test efficacy of HMB in free acid gel to decrease muscle damage, diminish inflammatory response, and improve muscle strength recovery following an acute exercise stress. HMB in a free acid gel or in CaHMB capsule form will be administered as either a single dose before a bout of acute exercise or in multiple doses (one before and three daily doses for the 4 days following the acute exercise). We hypothesize that HMB in free acid gel will result in less muscle damage, diminished inflammatory response, and improved muscle strength recovery than either a placebo or CaHMB treatment following a bout of acute eccentric exercise. Our endpoints will include measurements of: (1) markers for muscle damage (CPK and LDH); (2) indicators of inflammation (CRP, TNF-α, IL-6, IL-1ra and IL-18); and (3) muscle strength recovery and soreness.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	CaHMB	CaHMB capsules with each capsule containing 0.8 g of HMB
DIETARY_SUPPLEMENT	HMB Free Acid Gel	HMB Free acid in a gel form with each dose supplying 0.8 g of HMB free acid
DIETARY_SUPPLEMENT	Placebo	Placebo capsules similar in size and color to the CaHMB capsules used in the study
DIETARY_SUPPLEMENT	Placebo Gel Dosage	A corn syrup based placebo with flavoring and taste similar to the HMB Free Acid Gel

Timeline

• Start date: 2010-10-01
• Primary completion: 2010-11-01
• Completion: 2012-07-01
• First posted: 2010-06-25
• Last updated: 2012-07-18

Locations

1 site across 1 country: United States