NCT01149616

Effects of Perioperative Intravenous Dexamethasone on Pain in Out Patient Knee Surgery

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 82 (actual)
• Sponsor: Beth Israel Deaconess Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to determine the opiate sparing effects of intravenously administered dexamethasone in outpatient knee surgery. Dexamethasone is a glucocorticoid with well known antiemetic effects. However, the analgesic effects of dexamethasone have not been adequately researched. Following surgery, patients are typically discharged home with PO opiates to manage post-operative pain. The investigators believe that by using VAS (Visual Analog Scale) for Pain the investigators can show that a single dose of dexamethasone can reduce pain scales and opiate consumption post-operatively, on Post Operative Day (POD 1) when compared to placebo.

Detailed description

Findings of Modest improvement in pain scores and postoperative nausea at 24 hours with Dexamethasone

Conditions

• Post Operative Pain
• Nausea

Interventions

Type	Name	Description
DRUG	Dexamethasone 8mg iv x1	Dexamethasone 8mg iv x1
DRUG	placebo	2 ml normal saline IV x1

Timeline

• Start date: 2009-12-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2010-06-23
• Last updated: 2017-07-07
• Results posted: 2017-07-07

Locations

1 site across 1 country: United States